Updated: March 22, 2022

During its three season run, many actors made guest appearances, including familiar actors and / or actors who went on to become well-known. Among those appearing in Lost in Space episodes: Joe E. Tata, Alan Hewitt, Warren Oates, Don Matheson, Kurt Russell, Ford Rainey, Wally Cox, Norman Levitt, Tommy Farrell, Mercedes McCambridge, Lyle Waggoner, Albert Salmi, Royal Dano, Strother Martin, Michael J. Pollard, Byron Morrow, Arte Johnson, Fritz Feld, John Carradine, Al Lewis, Hans Conried, Dennis Patrick, Michael Rennie among many others. Future Hill Street Blues stars, Daniel J. Travanti (billed as "Danny Travanty") and Michael Conrad, made guest appearances on separate episodes.