Updated: November 03, 2023

During its three season run, many actors made guest appearances, including familiar actors and / or actors who went on to become well known. Among those appearing in Lost In Space episodes:

Joe E. Tata, Alan Hewitt, Francine York, Don Matheson, Kurt Russell, Ford Rainey, Warren Oates, Norman Levitt, Tommy Farrell, Lew Wagner, Lyle Waggoner, Albert Salmi, Royal Dano, Strother Martin, Michael J Pollard, Byron Morrow, Arte Johnson, Fritz Feld, Lew Gello, John Carradine, Al Lewis, Hans Conried, Dennis Patrick, Michael Rennie among many others. Future Hill Street Blues stars, Daniel J. Travanti (billed as "Danny Travanty") and Michael Conrad, made guest appearances on separate episodes. While Mark Goddard was playing Maj. West, he had a guest-appearance as well. Jonathan Harris, although a permanent cast member, was listed in the opening credits as "Special Guest Star" of every episode of Lost in Space.